SHAFAQNA Türkiye – The scientific world has mobilized against the CCHF virus, which occurs in more than 30 countries worldwide, is transmitted by tick bites and causes death because it cannot be cured. The search continues for vaccines and drugs to prevent the disease, which ranks second after Covid-19 in the list of diseases with the highest risk to public health according to WHO. While research into a vaccine against the CCHF virus is ongoing by various scientists at many universities, Turkish, American and Iranian scientists are also working together to develop a cure for the disease.
BLOOD SAMPLES OF SURVEYED PEOPLE
In the United States (USA) the Universities of Maryland, Georgia, Johns Hopkins and California and the US Army Medical Research Institute of Infectious Diseases and the Military Academy, in Turkey the Black Sea Technical University (KTU), Hittite and Acibadem Universities and the Pasteur Institute from Iran Turkey, took blood samples from people who had had CCHF.
Immunologists, virologists and microbiologists who conduct molecular studies on blood samples taken from 7 different recovered subjects; isolated natural antibody cells produced by the body after infection with a virus. In laboratory studies, scientists have broken down the basic immune cells that make antibodies in the blood into building blocks, and they have been able to create “monoclonal antibodies” that are specific to the CCHF virus. The study, which is the first step in cloning and replicating antibodies that target only the CCHF virus in the blood, and developing a cure for the deadly disease; It was converted into an article and presented to the scientific world. It is expected that the results of efficacy studies to be carried out on the 5 known strains of the virus will provide a glimmer of hope for the treatment of CCHF.
“THE MATTER CHANGES PERIODICALLY”
Faculty of Medicine KTU Farabi Hospital Head of the Department of Infectious Diseases prof. Dr. Gürdal Yılmaz said that CCHF has been observed in Turkey since 2002 and continues to be a problem. Stating that cases change periodically, Yılmaz said, “There has been an upward trend again in recent years. To date, we have admitted a third patient to our hospital. We are aware of mild cases in Gumuskhan. Since CHF is a problem, especially in our region and in countries like Iran, we need to conduct research on its treatment,” he said.
“ANTIBODIES HAVE BEEN MANUFACTURED AND USED TO TREAT COVID-19 DISEASE”
Explaining that they are looking for a common solution with the scientific world against CCHF disease, Prof. Dr. Yılmaz said: “As a result of our study, ‘monoclonal’ antibodies were obtained. These antibodies have finally been obtained and used to treat the Covid-19 disease. There are other diseases as well. A form of treatment designed specifically for the disease. Let’s say we’re trying to develop a drug that will trap the virus by giving this antibody to the CCHF virus from outside and destroying it there. We produce and reproduce from human blood. We took blood from our people who were sick and made antibodies with it. Antibodies taken from people who defeated the disease were produced and multiplied. We are now working on whether it is effective in other strains of CCHF,” he said.
“WE ARE TESTING EVENTS”
Explaining that they will test the effectiveness of all strains of the CCHF virus with “monoclonal” antibodies, Yılmaz said: “Manufacturing antibodies requires experience, not a complex process. An important point is to test the effectiveness of the produced antibody, and we are now conducting these tests. This article was published in Nature, one of the world’s leading scientific journals. We are looking at what we can do in future research. I hope it will be effective and we will not see deaths from CCHF.
“SUCCESSFUL PRODUCTION OF ANTIBODIES, HOPE FOR YOURSELF”
Noting that their results are the first step towards the development of drugs against the virus, prof. Dr. Yılmaz said: “The successful production of antibodies in itself means hope. We hope for the future. We think the test will be positive. CCHF will be treated; The first steps have been taken. In addition, a certain stage has been reached in vaccine research. Maybe a vaccine will protect us. There may not be a need for drugs such as “monoclonal” antibodies, but if they are needed, at least we have antibodies. Because there is no antiviral drug that works directly against the virus. ‘Monoclonal’ antibodies will help patients in this respect defeat this disease,” he said.
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