The Sunnybrook Health Sciences Center said in a written statement that the new technique marks the start of groundbreaking clinical trials to improve the treatment of deadly childhood tumors.
Recalling that DIPG is the most common form of brain tumor in children under 15 years of age, “DIPG is an inoperable, fatal childhood brain tumor due to its location in the brainstem.” it was said.
The following statements were included in the statement indicating the application of the new methodology:
“The new method works by using low-intensity ultrasound to cross the blood-brain barrier. The blood-brain barrier is a protective network of densely packed cells located between the capillaries of the brain and other soft tissues of the brain. This network of cells protects the brain from harmful substances and toxins. But when there is a problem in the brain, such as a tumor, the blood-brain barrier becomes an obstacle for doctors hoping to provide treatment for the affected areas.”
The statement, which was recorded when ultrasound came into play, said the researchers were able to open a temporary door in the blood-brain barrier around the brain using the power of the sound waves.
Blood-brain barrier temporarily crossed
In the extract to the patient intravenously, microscopic vesicles smaller than red blood cells description of the injection “Ultrasonic sound waves cause these microscopic bubbles to vibrate, expanding the space between the cells that make up the blood-brain barrier and creating temporary openings through which doses of chemotherapy can be delivered directly to the brain. These holes in the blood-brain barrier are temporary and about 12 hours after treatment, the blood-brain barrier will close again.” it was said.
Noting that the new method, also called focused ultrasound technology, is a novel and promising drug delivery strategy to cross the blood-brain barrier, it was reported that the first clinical trial could offer hope to children facing the deadly diagnosis of DIPG.
The application will be carried out on 10 more patients
This application, successfully implemented for the first time in the world, DIPG diagnosis It will be applied to 10 patients aged 5 to 18 years.
Study participants will receive guided ultrasound therapy at the Sunnybrook Health Sciences Center, which will include three rounds of chemotherapy about four to six weeks apart.
Patients who will receive general anesthesia will use a special helmet to deliver ultrasound energy to targets in the brain without scalpels or incisions. sputniknews
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